29 May Fenbendazole’s History
Dr. Gregory Riggins’ group at John Hopkins was recognized for investigating cancer-causing gene mutations as well as developing novel drugs in a preclinical setting before recommending them for further clinical trials.
The researcher and his colleagues had previously had no issue producing glioblastoma brain tumors in rats. However, one day scientists came upon a bunch of mice that had not developed any tumors.
The scientists explored the likely source of this unusual incident and discovered that the mice had been pre-treated with fenbendazole, a veterinary anthelmintic medicine.
This intriguing unintentional discovery prompted the researchers to do more study on the anticancer properties of fenbendazole and other benzimidazole compounds such as mebendazole, albendazole, niclosamide, and ivermectin.
According to the researchers, fenbendazole has a large safety margin and most animals, including people, tolerate it well. Previous safety tests in laboratory animals have revealed that this de-worming medication is extremely safe and has little toxicity risk.
This means that fenbendazole might be an excellent choice for anticancer therapy as one of the primary medications in several tumor treatment regimens as well as an adjunct to surgery, radiation, or chemotherapy.
Fenbendazole has grown in favor as a treatment option for cancer patients during the last decade. Nonetheless, evidence on fenbendazole effectiveness is limited because the medicine is already widely available around the world and pharmaceutical corporations cannot patent it to increase profits. As a result, no significant investors have emerged to take additional steps in finding knowledge on how fenbendazole may be used in common practice to prevent cancer.
People are currently sharing their experiences with this outdated medicine and its use in their cancer treatment journey on social media. Fortunately, there is enough toxicity and pre-clinical data to assist anyone interested in trying this veterinary medicine on how to avoid adverse effects and obtain a wider knowledge of how it may benefit in cancer therapy.
Finally, more clinical research may be able to address the major questions about how this molecule might help persons in need.